2-Octanone → 1-Nitro-5-hexyl-5-methyl-5,6-dihydropyrazolo[1,5-c]quinazoline

HRID 1659337Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:12][N:11]=[CH:10][C:9]=1[N+:13]([O-:15])=[O:14].[CH3:16][C:17]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=O>>[N+:13]([C:9]1[CH:10]=[N:11][N:12]2[C:8]=1[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][C:17]2([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH3:16])([O-:15])=[O:14]

Participants

Reactant 2

HCID 80932-Octanone

HCID 205602605-(o-Aminophenyl)-4-nitropyrazole

Product 1

HCID 1357377731-Nitro-5-hexyl-5-methyl-5,6-dihydropyrazolo[1,5-c]quinazolineYield 81.5%

Procedure

5-(o-Aminophenyl)-4-nitropyrazole is reacted with n-hexyl methyl ketone as given in Example 11 to give 1-nitro-5-hexyl-5-methyl-5,6-dihydropyrazolo[1,5-c]quinazoline. M.p.: 86°-88° C. Yield: 81.5%.

Sources & evidence

ORD record: ord-b6cd56602281493bafe67234a74e0de6
Source dataset: uspto-grants-1981_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04303660

Reaction notes

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