Glyoxylic Acid → 1-Nitro-5,6-dihydropyrazolo[1,5-c]quinazoline-5-carboxylic acid

HRID 1659340Notes

Reaction equation

HRID 1659340 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:12][N:11]=[CH:10][C:9]=1[N+:13]([O-:15])=[O:14].[C:16]([OH:20])(=[O:19])[CH:17]=O>>[N+:13]([C:9]1[CH:10]=[N:11][N:12]2[C:8]=1[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][CH:17]2[C:16]([OH:20])=[O:19])([O-:15])=[O:14]

Participants

3

Reactant 2

HCID 760Glyoxylic AcidHCID 205602605-(o-Aminophenyl)-4-nitropyrazole

Product 1

HCID 1357377711-Nitro-5,6-dihydropyrazolo[1,5-c]quinazoline-5-carboxylic acidYield 69%

Procedure

5-(o-Aminophenyl)-4-nitropyrazole is reacted with glyoxylic acid as described in Example 11 to give 1-nitro-5,6-dihydropyrazolo[1,5-c]quinazoline-5-carboxylic acid with a yield of 69%. M.p.: 203°-205° C.

Sources & evidence

ORD record
ord-5d034895b38f40759ed2876c0526d26d
Source dataset
uspto-grants-1981_12
Patent number
US04303660

Reaction notes

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