Acetic Anhydride → 1-Nitro-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline

HRID 1659341Notes

Reaction equation

HRID 1659341 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][N:7]2[C:16]=1[C:15]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:9][CH:8]2[CH3:17])([O-:3])=[O:2].[C:18](OC(=O)C)(=[O:20])[CH3:19]>O>[N+:1]([C:4]1[CH:5]=[N:6][N:7]2[C:16]=1[C:15]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:9]([C:18](=[O:20])[CH3:19])[CH:8]2[CH3:17])([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 1357377811-Nitro-5-methyl-5,6-dihydropyrazolo[1,5-c]quinazoline

Product 1

HCID 131756751-Nitro-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazolineYield 83%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

22.9 g (0.1 mole) of 1-nitro-5-methyl-5,6-dihydropyrazolo[1,5-c]quinazoline is boiled with 120 ml of acetic anhydride for 1 hour, then the solution obtained is poured into water. The product that solidifies is filtered off, washed with water and dried. Thus, 25.0 g (83%) of 1-nitro-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline are obtained. M.p.: 149°-150° C.

Workup

  1. customthe solution obtained
  2. filtrationThe product that solidifies is filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-5b8cc25e407e422ead6cdcd3255a6800
Source dataset
uspto-grants-1981_12
Patent number
US04303660

Reaction notes

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