HCID 135737780, compound → HCID 135737772, compound

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Reaction Steps

3.8 g (0.015 mole) of 1-nitro-5,5-dimethyl-5,6-dihydropyrazolo[1,5-c]quinazoline is reduced with hydrogen in ethanol in the presence of palladium/carbon. When the hydrogen consumption ceases, the catalyst is removed and the solvent is evaporated. Thus, 2.42 g (76%) of 1-amino-5,5-dimethyl-5,6-dihydropyrazolo[1,5-c]quinazoline are obtained. M.p.: 181°-183° C. The hydrochloride can be precipitated by treating the free amine in ethanol with anhydrous hydrogen chloride dissolved in ethyl acetate. M.p.: 244°-245° C.

Provenance & Evidence