Acetic Anhydride → HCID 135977804, compound

HRID 1659347Notes

Reaction equation

HRID 1659347 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][N:5]2[C:14]=1[C:13]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[NH:7][C:6]2([CH3:16])[CH3:15].[C:17](OC(=O)C)(=[O:19])[CH3:18]>N1C=CC=CC=1>[NH:1]([C:2]1[CH:3]=[N:4][N:5]2[C:14]=1[C:13]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[NH:7][C:6]2([CH3:16])[CH3:15])[C:17]([CH3:18])=[O:19]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 135737772HCID 135737772, compound

Product 1

HCID 135977804HCID 135977804, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

16.1 g (0.075 mole) of 1-amino-5,5-dimethyl-5,6-dihydropyrazolo[1,5-c]quinazoline are dissolved in 100 ml of pyridine. 80 ml of acetic anhydride are added and the reaction mixture is left to stand at room temperature for 1 day. The crystals separated spontaneously are filtered off and the mother liquor is evaporated. The collected crystals are washed with water and dried. Thus, 16.7 g (82%) of 1-acetamino-5,5-dimethyl-5,6-dihydropyrazolo[1,5-c]quinazoline are obtained. M.p.: 228°-230° C.

Workup

  1. waitthe reaction mixture is left
  2. customThe crystals separated spontaneously
  3. filtrationare filtered off
  4. customthe mother liquor is evaporated
  5. washThe collected crystals are washed with water
  6. customdried

Sources & evidence

ORD record
ord-aa6baf32857349b9b36c7e7e440de4c9
Source dataset
uspto-grants-1981_12
Patent number
US04303660

Reaction notes

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