HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 15170044, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 8-Methoxy-2-oxo-2H-chromene-3-carboxylic acid | HCID 234562 | — |
| Product | HCID 15170044 | HCID 15170044 | — |
Reaction Steps
A mixture of 8-methoxycoumarin-3-carboxylic acid (0.66 g) and thionyl chloride (2.5 ml) was heated under reflux for one and half hours. Distilling off the excess thionyl chloride in vacuo gave 8-methoxycoumarin-3-carboxylic acid chloride. Reaction of this product with amoxycillin, 1.257 g, in the same manner as in example 16, yielded D(-)-α-(8-methoxycoumarin-3-carbonamido)-p-hydroxybenzylpenicillin (0.95 g), melting at 187°-9° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04303664 |
| Source dataset | uspto-grants-1981_12 |
| ORD ID | ord-a21578e940074044b9c90f98399ba5d8 |
| Source note | uspto-grants-1981_12 |