HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 54206040, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 8-Hydroxy-3-carboxy-coumarin | HCID 7245716 | — |
| Product | HCID 54206040 | HCID 54206040 | — |
Reaction Steps
A solution of 8-hydroxycoumarin-3-carboxylic acid (2.06 g) in 10 ml thionyl chloride was heated under reflux for three hours, and 8-hydroxycoumarin-3-carboxylic acid chloride was obtained by distilling off the excess thionyl chloride. This was added in small portions to a methylene chloride solution (100 ml) containing ampicillin trihydrate (4.1 g) and triethylamine (3.5 ml) over a period of forty minutes under stirring and cooling on ice.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04303664 |
| Source dataset | uspto-grants-1981_12 |
| ORD ID | ord-145ae043c47144a1a03847e2e608308a |
| Source note | uspto-grants-1981_12 |