Dichloromethane → 3-(3-Amino-6-chloro-4-fluoro-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-1-yl)phenol
Reaction equation
[B:1]([Br:2])([Br:3])[Br:4].[Cl:35][CH2:36][Cl:37].[Cl:5][c:6]1[cH:7][c:8]([F:34])[c:9]2[c:13]([cH:14]1)[C:12]([c:15]1[cH:16][c:17]([C:21]([F:22])([F:23])[F:24])[n:18][cH:19][cH:20]1)([c:25]1[cH:26][c:27]([O:31][CH3:32])[cH:28][cH:29][cH:30]1)[N:11]=[C:10]2[NH2:33]>>[Cl:5][c:6]1[cH:7][c:8]([F:34])[c:9]2[c:13]([cH:14]1)[C:12]([c:15]1[cH:16][c:17]([C:21]([F:22])([F:23])[F:24])[n:18][cH:19][cH:20]1)([c:25]1[cH:26][c:27]([OH:31])[cH:28][cH:29][cH:30]1)[N:11]=[C:10]2[NH2:33]Participants
4
Sources & evidence
- ORD record
- ord-d10215ac52e9419abe712e5634330e36
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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