Sodium hydride → HCID 20559484, compound

Participants

Reaction Steps

Sodium hydride (0.8 g., 80% w/w dispersion in mineral oil) was added to a stirred solution of 2-[4-(4-chlorophenyl)phenyl]-ethanol (5.0 g.) in dimethylformamide (20 ml.). The mixture was stirred at room temperature under nitrogen for 5 hours. Ethyl 2-bromopropionate (3 ml.) was then added and the mixture was stirred at room temperature. After 18 hours the mixture was partitioned between ethyl acetate (100 ml.) and 4-N-hydrochloric acid (100 ml.). The organic phase was separated, washed with water (30 ml.), and evaporated to give ethyl 2-{2-[4-(4-chlorophenyl)phenyl]ethoxy}propionate as an oil (7.0 g.).

Provenance & Evidence