Hydrochloric Acid → HCID 131711642, compound

Participants

Reaction Steps

A suspension of 25 g. (0.048 moles) of 6-(α-[5-indanyloxycarbonyl]-phenylacetamido)-2,2-dimethyl-penam-3-carboxylic acid triethylammonium salt in 150 ml. of ethyl acetate is cooled to 0° C., and the suspension is acidified with 2 n aqueous hydrochloric acid (13 ml.) to pH=2. The organic phase is separated and the aqueous-acidic phase is extracted with 2×20 ml. of ethyl acetate. The organic solutions are combined, washed with 3×30 ml. of saturated aqueous sodium chloride solution, dried over magnesium sulfate, filtered, and neutralized with a solution of 6.7 g. (0.048 moles) of sodium diethylacetate in 30 ml. of acetone. About 50% of the solvent is evaporated in vacuo. 100 ml. of diisopropyl ether are added to the concentrate, the mixture is cooled, and the obtained white, powdery substance is filtered off. 18 g. (80%) of 6-(α-[5-indanyloxycarbonyl]-phenylacetamido)-2,2-dimethyl-penam-3-carboxylic acid sodium salt are obtained; m.p.: 220°-222° C.

Provenance & Evidence