Potassium Carbonate → HCID 20559535, compound

Participants

Reaction Steps

Add trifluoroacetamide (6.8 g=60 mmol) and potassium carbonate (8.0 g=60 mmol) to a solution of 4'-benzoyloxy-3'-methylthio-2-bromoacetophenone (11.0 g=30 mmol) in 200 ml acetonitrile. Reflux for 16 hours, allow to cool, filter, and concentrate. Dissolve the residue in ethyl acetate, wash with 1.0 N sodium hydroxide, then water. Dry, concentrate and treat the residue with ether to obtain the product as a yellow solid.

Provenance & Evidence