Potassium Iodide → HCID 12805910, compound

Participants

Reaction Steps

Combine 5-chloro-2-pentanone ethylene ketal (80 g=0.49 mol), N-methylaniline (52 g=0.49 mol), potassium carbonate (67 g=0.49 mol) and potassium iodide (8.1 g) in 250 ml dimethylformamide and heat at 100° C. for 16 hours. Allow to cool, partition between ether and water, and wash the ether twice with water. Dry, concentrate and distill to obtain 5-(N-methylanilino)-2-pentanone ethylene ketal, boiling point 104°-109° C./0.1 mm. Dissolve this (47 g=0.20 mol) in 400 ml 1.0 N hydrochloric acid with 100 ml ethanol. Let stand 2 hours, concentrate and adjust pH to about 8. Extract with ethyl ether, dry, concentrate and distill to obtain the product, having a boiling point 100°-104° C./0.1 mm pressure.

Provenance & Evidence