反应详情

30 grams of 3-nitro-4-hydroxyphenyl-α-methylacetic acid are dissolved in 500 ml of anhydrous ethanol, 1.5 g of 5% Pd on carbon are added, and hydrogenation is carried out at atmospheric pressure and ambient temperature. The catalyst is filtered off and the filtrate concentrated to a small volume. This is filtered, and crystallised from methanol. 24.5 g of raceme 3-amino-4-hydroxyphenyl-α-methylacetic acid are obtained, with a yield of 95%.

1. customis carried out at atmospheric pressure and ambient temperature
2. filtrationThe catalyst is filtered off
3. concentrationthe filtrate concentrated to a small volume
4. filtrationThis is filtered
5. customcrystallised from methanol