2-(2-Fluorobiphenyl-4-yl)-2-hydroxypropanoic acid → 2-(2-Fluoro-4-biphenylyl)acrylic acid

Participants

Reaction Conditions

Reaction Steps

The product of Example 1 (2 g.) was mixed with polyphosphoric acid (10 g.) and heated at 100° C. for 30 minutes. Water was added and the mixture stirred and extracted with ether. The extract was dried, filtered and evaporated to give crude 2-(2-fluoro-4-biphenylyl)acrylic acid in a yield of 91%, m.p. 169°-172° C. This was recrystallised from a mixture of ether and light petroleum (b.p. 40°-60° C.) to give pure material, m.p. 176°-177° C.

Provenance & Evidence