反应详情

60 g (0.15 Mol) of the methyl ester obtained in Example 1 are dissolved in 400 ml of methanol and 100 ml of 2 n methanolic sodium hydroxide solution is added thereto. This reaction mixture is stirred for 3 hours at room temperature. The solvent is then evaporated under reduced pressure and the residue dissolved in water. After acidifying with concentrated hydrochloric acid, the acid separates as viscous oil. After extraction with a mixture of ethyl acetate and toluene 1:1, and evaporation of the solvent, there remains 61.5 g of the above acid as a clear viscous oil.

1. customThe solvent is then evaporated under reduced pressure
2. dissolutionthe residue dissolved in water
3. extractionAfter extraction
4. additionwith a mixture of ethyl acetate and toluene 1:1, and evaporation of the solvent, there