Sodium Hydroxide → HCID 20478847, compound

HRID 1659660Notes

Reaction equation

HRID 1659660 reaction equation
C[O:2][C:3](=[O:27])[CH:4]([O:19][C:20]1[C:25]([Cl:26])=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][C:8]=1[C:17]#[N:18].[OH-].[Na+]>CO>[C:17]([C:8]1[CH:9]=[C:10]([C:13]([F:14])([F:15])[F:16])[CH:11]=[CH:12][C:7]=1[O:6][CH2:5][CH:4]([O:19][C:20]1[C:25]([Cl:26])=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:3]([OH:27])=[O:2])#[N:18]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54050450HCID 54050450, compound

Product 1

HCID 20478847HCID 20478847, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

60 g (0.15 Mol) of the methyl ester obtained in Example 1 are dissolved in 400 ml of methanol and 100 ml of 2 n methanolic sodium hydroxide solution is added thereto. This reaction mixture is stirred for 3 hours at room temperature. The solvent is then evaporated under reduced pressure and the residue dissolved in water. After acidifying with concentrated hydrochloric acid, the acid separates as viscous oil. After extraction with a mixture of ethyl acetate and toluene 1:1, and evaporation of the solvent, there remains 61.5 g of the above acid as a clear viscous oil.

Workup

  1. customThe solvent is then evaporated under reduced pressure
  2. dissolutionthe residue dissolved in water
  3. extractionAfter extraction
  4. additionwith a mixture of ethyl acetate and toluene 1:1, and evaporation of the solvent, there

Sources & evidence

ORD record
ord-9965f3360022459d8c6100aad8105f82
Source dataset
uspto-grants-1981_12
Patent number
US04304936

Reaction notes

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