HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl N-((4-hydroxypiperidin-4-yl)methyl)carbamate → Methyl 1-[(4-{[(tert-butoxycarbonyl)amino]methyl}-4-hydroxypiperidine-1-yl)methyl]cyclohexanecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl N-((4-hydroxypiperidin-4-yl)methyl)carbamate | HCID 10868112 | — |
| Reactant | Methyl 1-(iodomethyl)cyclohexanecarboxylate | HCID 58947958 | — |
| Product | Methyl 1-[(4-{[(tert-butoxycarbonyl)amino]methyl}-4-hydroxypiperidine-1-yl)methyl]cyclohexanecarboxylate | HCID 68584740 | — |
Reaction Steps
The title compound was prepared by a method similar to that shown in the Step 2 of Example 3 by using tert-butyl [(4-hydroxypiperidin-4-yl)methyl]carbamate (Chem. Pharm. Bull., 2002, 50 (9) 1187-1194) and methyl 1-(iodomethyl)cyclohexanecarboxylate (Step 1 of Example 6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07737163B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-f421c7f7466e48a39f178fd0a01ee711 |
| Source note | uspto-grants-2010_06 |