Acetic Anhydride → HCID 6793490, compound

HRID 1659739Notes

Reaction equation

HRID 1659739 reaction equation
[OH:1][N:2]=[C:3]([C:9]1[N:10]=[C:11]([NH2:14])[S:12][CH:13]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[C:15](OC(=O)C)(=[O:17])C>C(O)=O>[OH:1][N:2]=[C:3]([C:9]1[N:10]=[C:11]([NH:14][CH:15]=[O:17])[S:12][CH:13]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 6738988Ethyl 2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetate

Product 1

HCID 6793490HCID 6793490, compoundYield 76.7%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Ethyl 2-hydroxyimino-2-(2-aminothiazol-4-yl)acetate (syn isomer) (126.4 g), formic acid (81.3 g) and acetic anhydride (180 g) were treated in a similar manner to that of Preparation 12 to give ethyl 2-hydroxyimino-2-(2-formamidothiazol-4-yl)acetate (syn isomer) (109.6 g).

Workup

  1. customof Preparation 12

Sources & evidence

ORD record
ord-5149b140268047f18962be8f0502812e
Source dataset
uspto-grants-1981_12
Patent number
US04304770

Reaction notes

Loading…