Triphenylphosphine → (3R,7R)-1-bromo-3,7,11-trimethyldodecane

Participants

Reaction Steps

3.1 g (13.6 mmol) of (3R,7R)-3,7,11-trimethyl-1-dodecanol are treated with 4.02 g (15.3 mmol) of N-bromosuccinimide and 2.62 g (14.7 mmol) of triphenylphosphine in 13 ml of methylene chloride according to the method described above in Example 10. After chromatography and distillation, there are obtained 3.54 g (90%) of (3R,7R)-bromo-3,7,11-trimethyldodecane. B.p. 90°/0.05 Torr; [α]D20 =-3.6 (c=1.005, n-octane).

Provenance & Evidence