Sodium Chloride → 3-Ethyl-5-[2-(2,3-epoxypropoxy)-styryl]-isoxazole

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Reaction Steps

This compound is prepared, using the method described in Example V, from 5.1 g of 55% strength sodium hydride (0.116 mole), 25.0 g (0.116 mole) of 3-ethyl-5-(2-hydroxystyryl)-isoxazole and 15.9 g (0.116 mole) of epibromohydrin. The reaction mixture is poured into sodium chloride solution and the batch is extracted by shaking with diethyl ether. The ether solution is dried with anhydrous sodium sulfate and evaporated down. 29.2 g (93% of theory) of a colorless oil are obtained.

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