Benzocaine → Ethyl 4-[(pentadecafluoroheptyl)methylamino]benzoate

Participants

Reaction Steps

A solution of 45 g. of (pentadecafluoroheptyl)-(trifluoromethanesulfonyloxy)methane and 28 g. of ethyl 4-aminobenzoate in 50 ml. of hexamethylphosphoramide is stirred at 120° C. for 72 hours, diluted with water, and filtered. A methylene chloride solution of the solid is dried over anhydrous magnesium sulfate and evaporated. The residue is recrystallized from acetonitrile to yield the product as a white solid.

Provenance & Evidence