Sodium Hydroxide → HCID 20549396, compound

HRID 1659927Notes

Reaction equation

HRID 1659927 reaction equation
[F:1][C:2]([F:35])([F:34])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:33]=[CH:32][C:22]([C:23](=[O:31])[NH:24][CH2:25][C:26]([O:28]CC)=[O:27])=[CH:21][CH:20]=1.[OH-].[Na+]>C(O)C>[F:1][C:2]([F:34])([F:35])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:33]=[CH:32][C:22]([C:23]([NH:24][CH2:25][C:26]([OH:28])=[O:27])=[O:31])=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20549370HCID 20549370, compound

Product 1

HCID 20549396HCID 20549396, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 26.4 g. of ethyl 4-[15-(trifluoromethyl)pentadecylamino]hippurate, 110 ml. of 1 N sodium hydroxide solution; and 100 ml. of ethanol is stirred at ambient temperature for 2 hours and then partially evaporated. The aqueous solution is washed with diethyl ether, acidified with 6 N hydrochloric acid, and filtered. The solid is dried in vacuo and recrystallized from acetone to yield the product as a white solid.

Workup

  1. additionA mixture of 26.4 g
  2. custompartially evaporated
  3. washThe aqueous solution is washed with diethyl ether
  4. filtrationfiltered
  5. customThe solid is dried in vacuo
  6. customrecrystallized from acetone

Sources & evidence

ORD record
ord-57c9be769ed74106a672b177d50f7e9c
Source dataset
uspto-grants-1981_12
Patent number
US04305959

Reaction notes

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