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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1659944Generated: October 30, 2026

Ethyl 3-(4-aminophenyl)propanoate → Ethyl 4-[15-(trifluoromethyl)pentadecylamino]hydrocinnamate

https://huagongshe.com/reaction/1659944

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 3-(4-aminophenyl)propanoateHCID 10442595—
Reactant15-(Trifluoromethyl)pentadecyl bromideHCID 12797298—
ProductEthyl 4-[15-(trifluoromethyl)pentadecylamino]hydrocinnamateHCID 20549401—

Reaction Steps

In a manner directly analogous to that described in Example 8, ethyl 4-aminohydrocinnamate is alkylated with 15-(trifluoromethyl)pentadecyl bromide to form ethyl 4-[15-(trifluoromethyl)pentadecylamino]hydrocinnamate. Subsequently, in a manner directly analogous to that described in Example 9, ethyl 4-[15-(trifluoromethyl)pentadecylamino]hydrocinnamate is hydrolyzed to 4-[15-(trifluoromethyl)pentadecylamino]hydrocinnamic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04305959
Source datasetuspto-grants-1981_12
ORD IDord-8a18c338f7ab443693f06aca162a0a4c
Source noteuspto-grants-1981_12