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Methanol → Methyl-7-methylsulfamoyl-1,4-benzodioxane-5-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 2,3-Dihydro-7-(N-methylsulphamoyl)-1,4-benzodioxin-5-carboxylic acid | HCID 6455317 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Methyl-7-methylsulfamoyl-1,4-benzodioxane-5-carboxylate | HCID 54343297 | 85% |
反応手順
750 ml of methanol were introduced into a balloon flask provided with a condenser. Then, under cooling, 273 g of concentrated sulfuric acid and 160 g of 7-methylsulfamoyl-1,4-benzodioxane-5-carboxylic acid were added. The mixture was heated under reflux, cooled and poured into water and sodium carbonate. The precipitate was dried off, washed and dried. 143 g of methyl-7-methylsulfamoyl-1,4-benzodioxane-5-carboxylate were obtained (M.P.: 159°-160° C.; yield: 85%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04306072 |
| 出典データセット | uspto-grants-1981_12 |
| ORD ID | ord-e17156cb79404a8b8e55460874fde395 |
| 出典メモ | uspto-grants-1981_12 |