HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminomethyl-1-ethylpyrrolidine → N-(1-ethyl-2-pyrrolidylmethyl)-7-methylsulfamoyl-1,4-benzodioxane-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminomethyl-1-ethylpyrrolidine | HCID 117295 | — |
| Reactant | 7-Methylsulfamoyl-1,4-benzodioxane-5-carbonyl chloride | HCID 20544720 | — |
| Product | N-(1-ethyl-2-pyrrolidylmethyl)-7-methylsulfamoyl-1,4-benzodioxane-5-carboxamide | HCID 24834932 | 62% |
Reaction Steps
In a similar manner to that of the above example, 82 g of levorotatory 1-ethyl-2-aminomethyl-pyrrolidine was reacted with 195 g of 7-methylsulfamoyl-1,4-benzodioxane-5-carbonyl chloride to give 151 g of levorotatory-N-(1-ethyl-2-pyrrolidylmethyl)-7-methylsulfamoyl-1,4-benzodioxane-5-carboxamide (M.P.: 136°-137° C.; yields: 62%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04306072 |
| Source dataset | uspto-grants-1981_12 |
| ORD ID | ord-16259cf5fb004bbda65d76bef9dea231 |
| Source note | uspto-grants-1981_12 |