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Chlorosulfonic acid → 8-Methoxy-7-chlorosulfonyl-1,4-benzodioxane-5-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorosulfonic acid | HCID 24638 | — |
| 反応物 | 8-Methoxy-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic Acid | HCID 22734248 | — |
| 生成物 | 8-Methoxy-7-chlorosulfonyl-1,4-benzodioxane-5-carboxylic acid | HCID 20544748 | 98% |
反応手順
1045 cm3 of chlorosulfonic acid were introduced into a balloon flask provided with an agitator, a thermometer and a condenser and then, in portions, 110 g of 8-methoxy-1,4-benzodioxane-5-carboxylic acid were added with the temperature being maintained at from 5°-10° C. The mixture was agitated at ambient temperature and then poured on ice. The precipitate was dried off, washed and dried. 159 g of 8-methoxy-7-chlorosulfonyl-1,4-benzodioxane-5-carboxylic acid were obtained (yield: 98%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04306072 |
| 出典データセット | uspto-grants-1981_12 |
| ORD ID | ord-c3f3ee60cd844bfba15e4013bdd2eb2d |
| 出典メモ | uspto-grants-1981_12 |