HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-[(4-Methyl-1-piperazinyl)-carbonyl]-8-chloro-1,4-benzodioxane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 8-Chloro-1,4-benzodioxane-5-carbonyl chloride | HCID 20544746 | — |
| Reactant | 8-Chloro-2,3-dihydro-1,4-benzodioxin-5-carboxylic acid | HCID 23367046 | — |
| Product | 5-[(4-Methyl-1-piperazinyl)-carbonyl]-8-chloro-1,4-benzodioxane | HCID 20544702 | 50.6% |
Reaction Steps
According to the method described in Example 33, 20 g of 8-chloro-1,4-benzodioxane-5-carboxylic acid were treated with thionyl chloride and the resulting 8-chloro-1,4-benzodioxane-5-carbonyl chloride (M.P.: 83° C.) was treated with 10.5 g of methylpiperazine. 14 g of 5-[(4-methyl-1-piperazinyl)-carbonyl]-8-chloro-1,4-benzodioxane were obtained (M.P.: 260° C. with decomposition; yield: 50.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04306072 |
| Source dataset | uspto-grants-1981_12 |
| ORD ID | ord-843250c040594518afb29e1c94a51afc |
| Source note | uspto-grants-1981_12 |