Water → HCID 24977027, compound

Participants

Reaction Conditions

Reaction Steps

27.2 g (0.1 mol) of α,β-dibromo-isovaleric acid methyl ester were added dropwise to a solution of 19.9 g (0.2 mol) of cyanoacetic acid methyl ester and 10.8 g (0.2 mol) of sodium methylate in 50 ml of methanol at 20° C. The mixture was then heated to 64° C. for 5 hours. The solvent was then stripped off in vacuo. 100 ml of water and 100 ml of ether were added to the residue. The ether phase was separated off, dried over sodium sulphate and evaporated. The residue was fractionated twice. 12 g (57% of theory) of 3,3-dimethyl-1-cyano-cyclopropane-1,2-dicarboxylic acid dimethyl ester were obtained in the form of a colorless oil of boiling point 152° C./10 mm Hg.

Provenance & Evidence