Anisole → HCID 12804500, compound

Participants

Reaction Steps

A solution of 9.0 g (0.044 mol) of 4-methoxy-α,α,α-trifluoroacetophenone, 90 ml of anisole and 5 ml of trifluoromethyl sulfonic acid was stirred for 48 hours. At the end of this period, the product was worked up as in Example 6 to give 14.2 g (80%) of white crystalline 9; m.p. 196°-197° C., IR (KBr) 3010 (C--H, ar), 2840 (OCH3), 1610 and 1510 (Ar), 1150 (C--F) 825 cm-1 (parasubstituted phenyl); NMR δ 3.80 (s, 3H), 6.75 (d, J=8 Hz, 2H); 7.05 (d, J=8 Hz 2H); mass spectrum m/e, 402 (parent ion), 333 (P-69), 163 (P-239), 135 (P-267). Analytical: calculated for C23H2O3F3 ; C, 68.65; H, 5.22; F, 14.2%. Found: C, 68.48; H, 530; F, 14.2%.

Provenance & Evidence