HCID 135984350, compound → HCID 136053527, compound

Participants

Reaction Steps

A mixture of 4.56 g (0.01 M) of (S)-1-[3-(acetylthio)-2-methyl-1-oxopropyl]-L-proline, (5,6-dihydro-5-oxopyrazolo[1,5-c]-quinazolin-2-yl)-methyl ester and 200 cc 1.25 N of methanolic ammonia is stirred at room temperature under nitrogen for 2 hours. A clear solution forms after about 10 minutes. The solution is concentrated to dryness at 15 mm and 30° and the residue (4.4 g) dissolved in 250 cc 50% CHCl3 --CH2Cl2, washed with 2×150 cc H2O (to remove acetamide) and dried over MgSO4. The solution is concentrated to yield 3 g (75%) product, m.p. 140°-142° d.

Provenance & Evidence