2,4-Hexadienoic Acid → HCID 20557509, compound

HRID 1660124Notes

Reaction equation

HRID 1660124 reaction equation
[O:1]=[C:2]1[N:6]([CH2:7][CH2:8][C:9]([OH:11])=[O:10])[C:5](=[O:12])[NH:4][NH:3]1.[C:13]([OH:20])(=[O:19])[CH:14]=[CH:15][CH:16]=[CH:17][CH3:18]>C(#N)C>[C:13]([CH:14]1[CH:15]=[CH:16][CH:17]([CH3:18])[N:4]2[C:5](=[O:12])[N:6]([CH2:7][CH2:8][C:9]([OH:11])=[O:10])[C:2](=[O:1])[N:3]12)([OH:20])=[O:19]

Participants

4

Reactant 2

HCID 52512,4-Hexadienoic AcidHCID 13144543HCID 13144543, compound

Product 1

HCID 20557509HCID 20557509, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In a manner analogous to that described in Example 1(D), from 3,5-dioxo-1,2,4-triazolidine-4-propionic acid, prepared as described in Example 2(C) and hexa-2,4-dienoic acid, there was obtained in 76% yield 5-carboxy-2,3,5,8-tetrahydro-8-methyl-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-2-propionic acid of melting point 184°-186° C. (from acetonitrile).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-c56993df08784a1abdb09a31fe06d499
Source dataset
uspto-grants-1981_12
Patent number
US04307094

Reaction notes

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