5-carboxy-2,3,5,8-tetrahydro-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-2-acetic acid → 5-carboxy2,3,5,6,7,8-hexahydro-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-2-acetic acid

Participants

Reaction Steps

0.75 g of 5-carboxy-2,3,5,8-tetrahydro-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-2-acetic acid was dissolved in 50 ml of dioxan and hydrogenated in the presence of 10% palladium-on-charcoal at room temperature for 3 hours. The catalyst was filtered off and the filtrate was evaporated to give a colourless solid. This solid was recrystallized from acetonitrile to give 0.50 g (67%) of 5-carboxy2,3,5,6,7,8-hexahydro-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-2-acetic acid of melting point 224°-226° C. (from acetonitrile).

Provenance & Evidence