Benzyl bromoacetate → HCID 20557555, compound

Participants

Reaction Steps

1.50 g (0.007 mol) of methyl hexahydro-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-5-carboxylate were dissolved in 40 ml of dry tert.butanol. A solution of 0.87 g (0.008 mol) of potassium tert.butoxide in 50 ml of dry tert.butanol was added and the mixture was stirred under reflux and under a nitrogen atmosphere for 4 hours. 1.61 g (0.007 mol) of benzyl bromoacetate were added and the heating was continued for a further 4 hours. The mixture was filtered and the filtrate was evaporated to dryness. The residue was chromatographed on silica gel using chloroform for the elution to give 1.32 g (52%) of benzyl 5-methoxycarbonyl-2,3,5,6,7,8-hexahydro-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-2-acetate of melting point 103°-106° C. (from dichloromethane/hexane).

Provenance & Evidence