Formaldehyde → HCID 13144516, compound

Participants

Reaction Steps

7.02 g (0.033 mol) of methyl 2,3,5,8-tetrahydro-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-5-carboxylate and 9 ml of 40% aqueous formaldehyde were heated on a steam-bath for 4.5 hours. The mixture was evaporated in vacuo to give a colourless oil which was crystallized from dichloromethane/hexane, there being obtained 3.97 g (50%) of methyl 2-hydroxymethyl-2,3,5,8-tetrahydro-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-5-carboxylate of melting point 123°-125° C.

Provenance & Evidence