Formaldehyde → HCID 20557537, compound

Participants

Reaction Steps

2,3,5,8-Tetrahydro-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-5-carboxylic acid is reacted with formaldehyde in a manner analogous to that described in the preceding paragraph to give in 44% yield 2,3,5,8-tetrahydro-2-hydroxymethyl-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-5-carboxylic acid of melting point 175°-178° C. (from isopropanol). This acid is esterified using diazomethane in ether to give methyl 2-hydroxymethyl-2,3,5,8-tetrahydro-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-5-carboxylate of melting point 123°-125° C.

Provenance & Evidence