Hydrochloric Acid → HCID 54146493, compound

Participants

Reaction Steps

Methyl trans-2-(2-acetylthioethyl)-2,3,5,8-tetrahydro-1,3-dioxo-8-phenyl-1H-1,2,4-triazolo[1,2-a]pyridazine-5-carboxylate was hydrolyzed in 2-M hydrochloric acid at 100° C. for 3.5 hours. Partial evaporation then gave in 43% yield trans-2,3,5,8-tetrahydro-2-(2-mercaptoethyl)-1,3-dioxo-8-phenyl-1H-1,2,4-triazolo[1,2-a]pyridazine-5-carboxylic acid of melting point 153°-154° C.

Provenance & Evidence