HCID 70059102, compound → HCID 20557524, compound

Participants

Reaction Steps

4.73 g (0.013 mol) of ethyl cis-2-(2-chloroethyl)-2,3,5,8-tetrahydro-1,3-dioxo-8-phenyl-1H-1,2,4-triazolo[1,2-a]pyridazine-5-carboxylate were dissolved in 300 ml of ethanol and hydrogenated in the presence of 10% palladium-on-charcoal at room temperature. The catalyst was filtered off and the filtrate was evaporated to give 3.13 g (66%) of ethyl 2,3,5,6,7,8-hexahydro-2-(2-chloroethyl)-1,3-dioxo-8-phenyl-1H-1,2,4-triazolo[1,2-a]pyridazine-5-carboxylate of melting point 87°-89° C. (from ethanol).

Provenance & Evidence