HCID 20557557, compound → HCID 13144522, compound

HRID 1660140Notes

Reaction equation

HRID 1660140 reaction equation
C([S:4][CH2:5][CH2:6][CH2:7][N:8]1[C:20](=[O:21])[N:11]2[CH2:12][CH:13]=[CH:14][CH:15]([C:16]([O:18]C)=[O:17])[N:10]2[C:9]1=[O:22])(=O)C>C(OCC)(=O)C.CCCCCC>[SH:4][CH2:5][CH2:6][CH2:7][N:8]1[C:20](=[O:21])[N:11]2[CH2:12][CH:13]=[CH:14][CH:15]([C:16]([OH:18])=[O:17])[N:10]2[C:9]1=[O:22]

Participants

3

Reactant 1

HCID 20557557HCID 20557557, compound

Product 1

HCID 13144522HCID 13144522, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

In a manner analogous to that described in Example 32, from methyl 2,3,5,8-tetrahydro-2-(3-acetylthiopropyl)-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-5-carboxylate there was obtained in 35% yield 2,3,5,8-tetrahydro-2-(3-mercaptopropyl)-1,3-dioxo-1H-1,2,4-triazolo[1,2-a]pyridazine-5-carboxylic acid of melting point 119°-121° C. (from ethyl acetate/hexane).

Sources & evidence

ORD record
ord-997a2216bede4e5aa0079e69bffe6d5c
Source dataset
uspto-grants-1981_12
Patent number
US04307094

Reaction notes

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