1,3-Dichloroacetone → 4-(Chloromethyl)-2-methyl-1,3-thiazole--hydrogen chloride (1/1)

Participants

Reaction Steps

25.4 g of 1,3-dichloroacetone (0.2 mol) and 15 g of thioacetamide (0.2 mol), dissolved in 200 ml of absolute alcohol are stirred at 60°-70° for two hours. Subsequently, the solution is filtered and after evaporation in vacuo the residue is treated with 200 ml of ether. The 4-chloromethyl-2-methylthiazole, hydrochloride (32.8 g=89%) is filtered off and recrystallized from absolute alcohol (refrigerator); m.p. 168°-170° C.

Provenance & Evidence