(+-)-alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol → HCID 131712622, compound

HRID 1660149Notes

Reaction equation

HRID 1660149 reaction equation
[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[S:6][CH:7]=1.[Cl:15][C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:17]=1[CH:23]([OH:30])[CH2:24][N:25]1[CH:29]=[CH:28][N:27]=[CH:26]1>C(#N)C>[ClH:1].[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[S:6][CH:7]=[C:3]([CH2:2][O:30][CH:23]([C:17]3[CH:18]=[CH:19][C:20]([Cl:22])=[CH:21][C:16]=3[Cl:15])[CH2:24][N:25]3[CH:29]=[CH:28][N:27]=[CH:26]3)[N:4]=2)=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 32238(+-)-alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanolHCID 6102974-(Chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole

Product 1

HCID 131712622HCID 131712622, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the procedure of Example 1b, 4-chloromethyl-2-(4-chlorophenyl)thiazole (m.p. 66°) is reacted with 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol to yield the title compound, m.p. 108°-110° C. (acetonitrile).

Sources & evidence

ORD record
ord-d63ac5ca6e2646eca3fa1785a0858b3c
Source dataset
uspto-grants-1981_12
Patent number
US04307105

Reaction notes

Loading…