2-Bromopropiophenone → HCID 20558014, compound

Participants

Reaction Steps

N-phenethylthiourea (2.0 grams, 0.011 moles) and α-bromopropiophenone (2.34 grams, 0.011 moles, Aldrich Chem. Co.) in 10 ml absolute ethanol were heated to reflux temperature for 90 minutes under nitrogen. The ethanol was then removed under vacuum, excess ethyl acetate added and the solids filtered and dried over phosphorous pentoxide. Recrystallization from absolute ethanol yielded 2.86 grams (70%) of 2-phenethylamino-4-phenyl-5-methylthiazole hydrobromide, m.p. 172°-175° C.

Provenance & Evidence