Phenacyl bromide → HCID 20558012, compound

Participants

Reaction Steps

N-thenylthiourea (2.0 grams, 0.0116 moles) and α-bromoacetophenone (2.3 grams, 0.0116 moles, Aldrich Chem. Co.) in 15 ml absolute ethanol were heated to reflux temperature for 90 minutes under nitrogen. The reaction mixture was cooled and the ethanol removed under vacuum. On dissolving the residue in hot isopropyl alcohol and diluting with diethyl ether, an oil was formed. The diethyl ether was decanted, the oil dissolved in a small amount of ethanol and cooled. The resulting solids were filtered and dried over phosphorus pentoxide, yielding 3.20 grams (78%) of 2-thenylamino-4-phenyl-thiazole hydrobromide, m.p. 115°-118° C.

Provenance & Evidence