2-Chloro-4'-fluoroacetophenone → HCID 20558010, compound

Participants

Reaction Steps

N-thenylthiourea (0.80 grams, 0.0046 moles) and α-chloro-p-fluoroacetophenone (0.80 grams, 0.0046 moles, Aldrich Chem. Co.) in 11 ml absolute ethanol were heated at reflux temperature under nitrogen for 90 minutes. After cooling, and ethanol was removed under vacuum and the solids triturated with ethanol, filtered and vacuum dried over phosphorous pentoxide, yielding 0.848 grams (56%) of 2-thenylamino-4(p-fluorophenyl)-thiazole hydrochloride, m.p. 184°-187° C.

Provenance & Evidence