Acetic Anhydride → 2-Acetamido-alpha,alpha,alpha-trifluoro-p-toluic acid

Participants

Reaction Steps

3 g. of 2-amino-α,α,α-trifluoro-p-toluic acid is dissolved in 20 ml. of acetic anhydride and the resultant solution is heated to 80° C. After 30 minutes at a temperature of 80° C., the excess acetic anhydride is removed from the reaction mixture on a rotary evaporator and water is added to the residue. The resultant precipitate is filtered, washed with water and dried to yield 2-acetamido-α,α,α-trifluoro-p-toluic acid (N-acetyl-4-trifluoromethylanthranilic acid), m.p. 195°-197° C.

Provenance & Evidence