HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl isothiocyanate → N-methyl-N'-[2-((1,4-dimethyl-2-imidazolyl)methylthio)ethyl]thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | 1,4-Dimethyl-2-[(2-aminoethyl)thiomethyl]imidazole | HCID 12788954 | — |
| Reactant | Ethanol ethylacetate | HCID 21584252 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-methyl-N'-[2-((1,4-dimethyl-2-imidazolyl)methylthio)ethyl]thiourea | HCID 20557738 | — |
Reaction Steps
The reaction of 1,4-dimethyl-2-[(2-aminoethyl)thiomethyl]imidazole (derived from the 6.2 g. dihydrobromide) with methyl isothiocyanate (1.34 g.) in ethanol (50 ml.) followed by chromatography on a column of silica gel with ethyl acetate-ethanol (9:1) as eluant gave N-methyl-N'-[2-((1,4-dimethyl-2-imidazolyl)methylthio)ethyl]thiourea (2.1 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04307101 |
| Source dataset | uspto-grants-1981_12 |
| ORD ID | ord-e70908eae49848b99fd7311f34896940 |
| Source note | uspto-grants-1981_12 |