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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1660197Generated: October 29, 2026

Thionyl Chloride → 3-(2-Hydroxyethoxymethyl)pyrazole

https://huagongshe.com/reaction/1660197

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
ReactantSodiumHCID 5360545—
ReactantHCID 178478439HCID 178478439—
ReactantHCID 178519763HCID 178519763—
SolventEthylene GlycolHCID 174—
Product3-(2-Hydroxyethoxymethyl)pyrazoleHCID 178521430—

Reaction Steps

3-Chloromethylpyrazole, prepared by reacting 3-hydroxymethylpyrazole with thionyl chloride, is reacted with the sodium salt of ethylene glycol to give 3-(2-hydroxyethoxymethyl)pyrazole. Treatment of 3-(2-hydroxyethoxymethyl)pyrazole with thionyl chloride gives 3-(2-chloroethoxymethyl)pyrazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04307101
Source datasetuspto-grants-1981_12
ORD IDord-4a713cb092d346bea9cae195c1f1725b
Source noteuspto-grants-1981_12