Methyl Isocyanate → N-Methyl-N'-[2-(2-pyrimidylmethylamino)ethyl]urea

HRID 1660215Notes

Reaction equation

HRID 1660215 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:2]1[N:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[O:15]

Participants

3

Reactant 2

HCID 12228Methyl IsocyanateHCID 20557649N-(2-pyrimidylmethyl)ethylenediamine

Product 1

HCID 20557658N-Methyl-N'-[2-(2-pyrimidylmethylamino)ethyl]urea

Procedure

By the procedure of Example 24, N-(2-pyrimidylmethyl)ethylenediamine is reacted with methyl isocyanate to give, after concentrating and separating the residue by column chromatography, the title compound.

Workup

  1. customto give
  2. concentrationafter concentrating
  3. customseparating the residue by column chromatography

Sources & evidence

ORD record
ord-fc46e71228514eef9fd8a224ad8c6984
Source dataset
uspto-grants-1981_12
Patent number
US04307101

Reaction notes

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