Methyl Isocyanate → N-Methyl-N'-[2-((4-bromo-3-isothiazolyl)methylthio)ethyl]urea

HRID 1660235Notes

Reaction equation

[Br:1][C:2]1[C:3]([CH2:7][S:8][CH2:9][CH2:10][NH2:11])=[N:4][S:5][CH:6]=1.[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:11][CH2:10][CH2:9][S:8][CH2:7][C:3]1[C:2]([Br:1])=[CH:6][S:5][N:4]=1)=[O:15]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 129234142-{[(4-Bromo-1,2-thiazol-3-yl)methyl]sulfanyl}ethan-1-amine

Product 1

HCID 20557927N-Methyl-N'-[2-((4-bromo-3-isothiazolyl)methylthio)ethyl]urea

Procedure

Reacting 4-bromo-3-[(2-aminoethyl)thiomethyl]isothiazole with methyl isocyanate by the procedure of Example 24 gives the title compound.

Sources & evidence

ORD record: ord-83688d01d8e64b7eb139f0472d6c4eea
Source dataset: uspto-grants-1981_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04307101

Reaction notes

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