1,3-Propanediamine → 2-(3-Aminopropylamino)-1,3,4-thiadiazole

HRID 1660258Notes

Reaction equation

HRID 1660258 reaction equation
Br[C:2]1[S:3][CH:4]=[N:5][N:6]=1.[NH2:7][CH2:8][CH2:9][CH2:10][NH2:11]>>[NH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:2]1[S:3][CH:4]=[N:5][N:6]=1

Participants

3

Reactant 2

HCID 4281,3-PropanediamineHCID 27951982-Bromo-1,3,4-thiadiazole

Product 1

HCID 205577472-(3-Aminopropylamino)-1,3,4-thiadiazole

Procedure

By the procedure of Example 188, 2-bromo-1,3,4-thiadiazole is reacted with 1,3-diaminopropane to give 2-(3-aminopropylamino)-1,3,4-thiadiazole and this intermediate is reacted with methyl isothiocyanate to give N-methyl-N'-[3-(2-(1,3,4-thiadiazolyl)amino)propyl]thiourea.

Sources & evidence

ORD record
ord-b4cd6ff9763a4ed5a4c424eb1ac5aac1
Source dataset
uspto-grants-1981_12
Patent number
US04307101

Reaction notes

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