Dicyclohexylcarbodiimide → HCID 54402895, compound

Participants

Reaction Conditions

Reaction Steps

N,N'-Dicyclohexylcarbodiimide (1.11 g) is added to a suspension, cooled to +4° C., of 2-methoxyimino-2-(2-tritylamino-thiazol-4-yl)-acetic acid, syn isomer (2.17 g) and 4-(2-tert.-butyoxycarbonylamino-ethyl)-5,6-dioxo-3-thioxo-perhydro-1,2,4-triazine (1.05 g) in ethyl acetate (50 cc). The mixture is stirred for 4 hours at 20° C., filtered and concentrated to dryness at 20° C. under 20 mm Hg (2.7 kPa). The residue is taken up in methylene chloride (20 cc) and the solution is poured into diisopropyl ether (250 cc). After filtration and drying, 4-(2-tert.-butoxycarbonylamino-ethyl)-5,6-dioxo-3-[2-methoxyimino-2-(2-tritylamino-thiazol-4-yl)-acetylthio]-1,4,5,6-tetrahydro-1,2,4-triazine (syn isomer) (0.73 g) is obtained in the form of a yellow powder.

Provenance & Evidence