1-Ethyl-2-methyl-1H-indole-3-carbaldehyde → 1H-Indole, 1-ethyl-2-methyl-

HRID 1660411Notes

Reaction equation

HRID 1660411 reaction equation
C1(C)C=CC(S([O-])=O)=CC=1.[Na+].[CH2:12]([N:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16](C=O)=[C:15]1[CH3:25])[CH3:13]>>[CH2:12]([N:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[C:15]1[CH3:25])[CH3:13]

Participants

3

Reactant 2

HCID 9565841-Ethyl-2-methyl-1H-indole-3-carbaldehydeHCID 2723791Sodium p-toluenesulfinate

Product 1

HCID 1704321H-Indole, 1-ethyl-2-methyl-

Procedure

Following a procedure similar to that described in 3A but employing 6.5 g. of 85.9% sodium p-toluenesulfinate, 4.6 g. of 1-ethyl-2-methyl-1H-indole-3-carboxaldehyde and 3.8 g. of 1-ethyl-2-methyl-1H-indole there was obtained 4.5 g. of 3-[(1-ethyl-2-methyl-1H-indol-3-yl)(4-methylphenylsulfonyl)methyl]-1-ethyl-2-methyl-1H-indole, m.p. 146°-152° C.

Sources & evidence

ORD record
ord-23425fbfff4e46a6bc0031723215b1b7
Source dataset
uspto-grants-1981_12
Patent number
US04307898

Reaction notes

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